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SmartScope is a framework for automated cryo-electron microscopy (Cryo-EM). The main purpose is to automate specimen screening, document the process, and provide a portal for visualization and interaction with the microscope. The software bundles a database, the main imaging workflow and a web user-inteface for easy access. To run Smartscope, simply fill the form about which grids to be screened, press start and wait for live results to come in.